الفهرس 
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Abstract
Our work was carried out to study the role of fish in transmitting some zoonotic diseases either parasitic or bacterial one to human. Experimental infestation of 10 puppies by suitable dose of fish flesh containing viable H. heterophyes metacercarae (300 metacercarae) resulted in clinical signs. These signs in dead and scarified puppies were abdominal pain, diarrhea, which may be bloody. Moreover, anorexia then dehydration and death were also declared. Mortality rate was 10%. Macroscopically, the mucosa at small intestine was congested and covered with slimy mucus. Payer’s patches became obvious and prominent raised area. Mesentric lymph nodes were enlarged and edematous while large intestine mucosa was edematous, red and may contain bloody diarrhea inside their lumina, liver was enlarged and congested. Lungs were edematous and showed focal hepatization. In addition to partial metaplasia of enterocytes to goblet cells. Thickening of the lamina propria by edema together with the presence of lymphocytes and plasma cells infiltration in mucosa and submucosa. Segments of the parasites were embedded between the intestinal villi. Liver showed mainly hyDROPic degeneration and development of granuloma around distructed egg shell. Lungs showed eosinophilic pneumonia. Other areas showed pneumonic areas alternated with emphysema. Other area showed bronchlitis, fibrosis and granuloma formation around egg shell. Kidneys showed granulomas in renal parenchyma. Other area showed coagulative necrosis in some renal tubules. Spleen showed multiple areas of coagulative necrosis in the white pulps. No lesions were found in brain. Experimental infection of 27 rabbits was done by a dose of 1 and 2 ml of 24 hr nutrient broth culture containing 9 x 108 CFU/ml. orally. In our study we choose rabbit as a model for human because it is very susceptible for Aeromonoas hyDROPhila. Clinically, all dead and sacrificed rabbits suffered from fur DROPping, respiratory manifestation, profuse watery diarrhea followed emaciation, extensive loss of body weight and death. Mortality rate was 40%. Macroscopically, all dead and scarified rabbits were emaciated with presence of serious fluids inside the body cavities and brain. Intestine was distended with watery diarrhea and gases accompanied with congested organs and major blood vessels. Lungs showed focal area of hepatization. Microscopically, small intestine showed catarrhal enteritis accompanied partial desquamation of enterocytes or converted to goblet cells. Infiltration by neutrophils at inter-glandular space of submucosa and lamina propria were seen. Large intestine showed conversion of all interstatial glands to goblet cell. Liver, showed dilated portal blood vessels with degenerative changes in the hepatic cells accompanied by formation of numerous bile ductules, lymphocytic infiltrations and few extravasated erythrocytes. Mild periductal fibroblastic proliferation could be seen. Hypertrophy of Kupffer’s cell, peliosis and or telanjectasis could be seen. Lungs showed multiple perivascular lymphocytic aggregations with hyperplastic peribronchial lymphoid follicles. Other area showed focal disseminated pneumonic areas accompanied by leukocytic infiltrations. Kidneys showed non suppurative nephritis. Brain showed demylination in some nerve axons, hemorrhages, focal gliosis and granuloma. Pancreas showed no lesions except stagnant secretion in some acini.