الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
The present work was conducted to study the protective effect of Spirulina platensis on histopathological, ultrastructural, histochemical and immunohistochemical changes induced by 7, 12 Dimethylbenz[a]anthracene in the mammary gland of female virgin rats.In this study, rats were divided into four groups. Body weight was recorded weekly, In the present investigation, histopathologiacal examination of the epithelium of the mammary gland of DMBA treated rats showed that the developed cancer could be classified into three types: Lobular carcinoma in situ, Comedo carcinoma, Carcinoma simplex. Moreover, histopathological and histochemical examinations of mammary alveoli of rats protected with Spirulina against the carcinogenicity of DMBA showed the desquamation of most of the neoplastic cells of the three types of tumours leaving only one or two layers or the basal lamina was completely denuded of epithelial cells. Apoptosis and necrosis of the cancer cells were desquamated away. Immunohistochemically, the mammary epithelium of DMBA treated rats showed a very high significant increase in the Ki-67 LI and OR LI with respect to control and/or Spirulina treated rats. Spirulina was found to be of great curative and preventive effects.