الفهرس 
Introduction & Aim of WorkOnly 14 pages are availabe for public view
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Abstract
This study was designed to assess the regulatory role of glucocorticoids and catecholamines on leptin hormone secretion from adipose tissue of male rats trying to help in understanding the pathogenesis of obesity. This work was done on two main groups of rats , the first group included average weight rats their weights ranged from 120 to 220 grams while the other group included obese rats their weights ranged from 440 to 550 grams. The p The prepared adipose tissue was added to the media under sterilized condition as follows for each rat, one sample added to the non supplemented medium (control medium), the second sample was added to the dexamethasone supplemented medium, the third sample is added to the isoprenaline supplemented medium. After addition o f the samples to the wells aseptically‚ the plates were transferred to the incubator to be incubated at temperature 37˚C &Co2 atmosphere Leptin leptin levels were assessed after 6 h , 24 h and 72 h. It was found that glucocorticoids stimulated leptin secretion in both average weight and obese rats, this stimulatory effect was non significant after 6 h but became significant after 24 h and 72 h , however isoprenaline inhibited leptin secretion in both average weight and obese rats, this inhibitory effect was significant after 6 h , 24 h and 72 h.