الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Programmed cell death is genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. Survivin is an inhibitor of apoptosis of the IAP gene family. It has a role in counteracting apoptosis and regulating cell division. This study was designed to assess serum survivin protein level in newly diagnosed leukemic patients versus leukemic patients who developed remission and also versus the control group. In addition, a correlation study was held on between serum survivin level and some Biochemical and hematological parameters in the newly diagnosed leukemic cases This study presents the following data: -Survivin was detected in 80.9% of the newly diagnosed leukemic cases; while it was below the detection level in both the control group, and the leukemic patients who are in remission. -Serum survivin level showed no significant difference between ALL and AML cases. It showed higher levels in patients who are more suffering from bad clinical presentation. - positive significant correlation was found between serum survivin level and some bad prognostic biochemical and hematological parameters. In conclusion assessment of serum survivin level may be a useful tool for diagnosis and prediction of prognosis in acute leukemic cases.