الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Preparation of new series of [1,3,4]thiadiazolo[3,2a]pyrimidines and their evaluation as anticancer agents. The structures of these compounds were determined by elemental analysis and some of them were studied by IR, 1HNMR, and mass spectrometry. Fifteen of the newly synthesized final compounds were screened in vitro and in vivo for their anticancer activity, the obtained results indicated that three of these compounds have strong DNA binding affinity. These compounds with DNA binding affinity were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC) in mice using 5fluorouracil (5FU) as a positive control The results indicated they have antitumor activity against EAC in mice.