الفهرس 
Introduction & Aim of workOnly 14 pages are availabe for public view
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Abstract
Endometrial carcinoma (EC) is the most common invasive malignancy of the female genital tract in developed countries. Immunohistochemical analysis (IHC) of Fragile Histidine Triad (FHIT), Vascular Endothelial Growth Factor (VEGF) and Estrogen Receptors (ER) expression is an important point in histopathological evaluation of cases of endometrial carcinoma. This significance stems from the prognostic value of expression of these markers as predictors of outcome and decision-making biomarker for aggressive treatment of endometrial carcinoma The aim of this work is to study total abdominal hysterectomy specimens harboring endometrial carcinoma (71 cases) received at Pathology Department, Mansoura Faculty of Medicine. Using IHC to detect the expression of FHIT, VEGF and ER. Correlation between FHIT, VEGF expression and different clinicopathological parameters as well as ER status. The age of patients included in this study ranged from 30 to 85 with median age 57 years. Sixty-seven cases (94%) were type 1, while the remaining 4 cases (6%) were categorized as type 2. FIGO grade 1 was the most frequent, accounting for 39% of cases. Most of the studied patients were stage I (62 %), none of them belonged to stage IV. Necrosis within tumour tissue was encountered in 42 cases (59%). Necrosis was more often in tumours infiltrating more than 50 % of myometrial thickness. Vascular emboli are encountered in 46 cases (56 %). Vascular invasion was more prevalent in tumours infiltrating more than half of myometrial thickness than more superficial tumours. Vascular invasion was more frequently seen in tumours possessing infiltrative margins than those having pushing margins (67 % versus 20 %). Considerable degree of correlation was found between the level of expression of these markers and most of the clinicopathological parameters especially, tumour grade and stage. There was a significant correlation between FHIT and ER expression as both of them tend to be lost in late stages of the disease. A significant negative correlation was elucidated between VEGF and ER expression. Conclusion: The information derived from the effect of these tumour markers on prognosis will reduce the need for extensive surgery and adjuvant radiation therapy. Furthermore, application of these markers on curetting materials may predict the stage, extent of tumour and the possibility of vascular invasion prior to surgery.