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العنوان
Relationship between cytokines and sperm functions in male infertility \
المؤلف
Abd El­Monem, Noha Mohamed Hazem.
هيئة الاعداد
باحث / نهم محمد حازم عبدالمنعم
مشرف / هدى أحمد ندا
مشرف / محب منصور عبدالرزاق
مناقش / عادل عبدالقادر زلطه
مناقش / عصام محمد نور الدين
الموضوع
Cytokines and sperm - Functions. Cytokines - physiology. Infertility, Male - Diagnosis.
تاريخ النشر
2006.
عدد الصفحات
226 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء الحيوية (الطبية)
تاريخ الإجازة
1/1/2006
مكان الإجازة
جامعة المنصورة - كلية الطب - Medical Biochemistry Department
الفهرس
Only 14 pages are availabe for public view

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Abstract

In this study , semen parameters of infertile men were compared with fertile control group . Methods : A total of 68 male (20 varicocele, 15 accessory sex gland inflammation , 16 idiopathic infertility ,and 17 control ) were evaluated .Evaluation included medical history , physical examination , hormone analysis ,semen analysis , the hypo­osmotic swelling ( HOS ) test . The seminal plasma was analysed for IL 8, malondialdehyde , and the suspensions of spermatozoa were extracted for nucleotides separation. Results : IL­8 concentrations were highly significantly increased in MAGI group compared with control , varicocele , and idiopathic groups . Seminal plasma concentration of malondialdehyde (MDA) per 10 8 sperm was highly significantly increased in MAGI , varicocele , and idiopathic groups than in the control group. The levels of ATP, GTP , CTP( UTP ) , (NS(BAMP , (NS(BGMP , (NS(BCMP , and (NS(BUMP were highly significantly decreased in MAGI , varicocele , and idiopathic groups as compared with the control group . The results of HOS test were highly significantly lower in MAGI , varicocele , and idiopathic groups compared with the control group. Conclusion : Male infertility is a multi­factorial medical problem. Determination of IL­8 in the seminal plasma of infertile patients with genital infection provides clinically useful information . It was revealed that excess oxidants production is of great deleterious impact on sperm quality and male fertility potential. Also , the presented data suggest variant types of nucleotides to affect the fertilizing capacity of the spermatozoa.