الفهرس | Only 14 pages are availabe for public view |
Abstract Twenty adult rats were subjected to parasympathetic denervation of the right submandibular gland by excision of chorda tympani nerve, in addition ten rats were subjected to sham?s operation and were used as control. The speciemenes prepared after 2,4,6 and 8 weeks after denervation for Hx & Eosin, PAS, transmission electron microscopy and semithin sections (stained with toluidine blue). The parasympathetic denervated speciemens showed progressive degenerative changes in acini, diltatation of striated ducts and increase connective tissue between atrophic acini appeared from 2 weeks and increase progressively in 6 and 8 weeks. While section of 2, 4, 6 and 8 weaks after parasympathectomy showed weak PAS reactivity in acini, striated and interlobular ducts. In toluidine blue semithin sections after parasympathectomy showed gradual increase in vacuolated cytoplasm lining the acini and ducts amd less number of dark blue granules in the granular convoluted tubules. While in ultrathin section after parasympathectomy their were small irregular nuclues, degenerated mitochondria, few zymogen granules, dilated rough endoplasmic reticulum and plenty of phagocytosed apoptotic bodies. On the other hand intact normal acinar cells were seen scattered in the section, which indicate that the submandibular gland is supplied by other routs than the chorda tympani nerve. |