الفهرس 
Introduction & Aim of the Work
Splenic MicrostructureOnly 14 pages are availabe for public view
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Abstract
Study Objectives: The aim of this prospective randomized study is to investigate the safety, efficacy and complications of using partial splenic embolization in treating hypersplenism compared with surgical splenectomy. Methods: This study was conducted for evaluation of the safety, efficacy and complication of using partial splenic embolization (PSE) in treating hypersplenism compared with surgical splenectomy. The study included 40 patients, 29 males and 11 females with a mean age of 39 years with secondary hypersplenism due to portal hypertension. They were admitted to General Surgery Department, Mansoura University Hospital between November 2002 and April 2005. All patients were subjected to thorough history taking, clinical examination, full laboratory investigation, upper gastrointestinal endoscopy, abdominal US and duplex Scan. RESULTS: In group I there was only one mortality recorded, while in group II no mortality was recorded. PSE was a significant rapid procedure compared to splenectomy, and PSE patients had significantly shorter hospital stay than splenectomy patients. No blood transfusion was needed in group I while in group II mean blood transfusion was 2 units. In the second group, four patients had postoperative fever 39C, three patients had portal vein thrombosis and one of them developed mesenteric vascular occlusion later on, two patients had postoperative ascites and one patient had postoperative wound infection. Pancreatitis and OPSI did not occur in any of our patients. CONCLUSIONS: The embolization should be partial, and preferably within one of the polar branches of splenic artery, to minimize discomfort and to decrease the risk of massive necrosis of splenic tissue with subsequent splenic abscess, and to avoid thrombosis of splenic, portal and pancreatic veins. Among other advantages, it is relatively easy to perform, has minimal morbidity, the splenic vein is preserved, and a portion of the splenic parenchyma remains intact to carry on the immunologic roles.