الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Background: Psoriasis is a chronic inflammatory skin disorder that is presently without a permanent cure. Up to 40% of patients with psoriasis also develop psoriatic arthritis. The exact mechanism of psoriasis is still unclear, the involvement of Tcellmediated. Cytokine expression in the aetiology of psoriasis is becoming clearer. The goal of modern treatment is to target such immune responses that lead to the formation of psoriatic plaques and psoriatic arthritis using selective immunomodulating pharmacotherapy. The advantages of these biological agents are less toxic systemic sideeffect profiles that will improve the quality of life in psoriatic patients. Objectives: this review article describes current and emerging selective immunomodulators of psoriasis, and will briefly discuss disease immunopathogenesis. Methods literature review: Results and conclusions: given the role of the inflammatory immune responses in the pathogenesis of psoriasis, the goal of modern medicine and pharmacotherapy lies in the design and use of specific targets in cellmediated immune reactions and the modulation of the expression of various inflammatory cytokines.