الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Background Aluminum is the most abundant metal in the earth’s crust. Its widespread occurrence, both in food and environment, makes it impossible for man to avoid exposure to this metal ion. The accumulation of aluminum, in some patients with chronic renal failure, is associated with the development of toxic phenomena; dialysis encephalopathy, dialysis osteodystrophy and anemia. Aluminum accumulation also occurs in patients who are not on dialysis, predominantly in infants and children with immature or impaired renal function. Aluminum has also been considered as a toxic agent in the etiology of Alzheimer’s disease and Parkinsonian-dementia Aim of Work: to study the effect of prolonged administration of aluminum on the structure of the renal cortex of adult albino rats. Materials and methods: Eighty adult male albino rats ranging in weight from 100-200 grams were used in this study and were classified into 2 equal groups:- Group (I) animals were given drinking water daily for 4 months by means of the gastric tubes. Group (II) rats were given aluminum salt (powder form) in a dose of 5mg./kg.body weight dissolved in drinking water daily for 4 months by means of the gastric tubes. Results: Effects of aluminum administration on renal cortex had been shown in these studies which were widening and necrosis of renal tubules, congestion and fibrosis of renal glomeruli. Conclusions: from the present study we concluded that, aluminum is highly nephrotoxic. Therefore, it is better to be avoided as possible in spite of its world wide existence, especially in patients with chronic renal failure and also those on dialysis.