الفهرس 
Introduction and aim of work
Acute leukemiasOnly 14 pages are availabe for public view
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Abstract
Angiogenesis is the formation of new capillaries from preexisting blood vessels. It has physiological roles. It plays an important role in progression of solid tumors. Recently a similar relationship has be described in several hematologic malignancies. Basic fibroblast growth factor (bFGF). bFGF also is known as FGF2 is a powerful stimulator of angiogenesis, and is a potent hematopoietic growth factor. bFGF can play an important role in tumor formation and progression in both solid tumors and hematological malignancies previous studies found that serum levels of bFGF were increased at time of diagnosis in patients with acute leukemia in both ALL and AML patients. This study was conducted on 30 virgin cases with acute leukemia (15 cases with ALL and 15 cases with AML). 19 patients were taken after chemotherapy in remission state (12 cases with ALL and 7 cases with AML). The study also included 14 patients with acute leukemia in relapse (7 cases with ALL and 7 cases with AML) and the serum levels of bFGF were estimated in the above groups by ELISA technique. The results of the present study were: Serum levels of bFGF were significantly increased in virgin and relapsed cases of children with ALL compared to control group. Serum levels of bFGF were significantly decreased in children with ALL in remission compared to virgin and relapsed cases with ALL. Serum levels of bFGF were significantly increased in virgin cases of children with AML compared to control group. Serum levels of bFGF were significantly decreased in children with AML in remission compared to virgin cases with AML. In conclusions: bFGF, as one of angiogenic factors plays an important role in pathogenesis of pediatric acute leukemia (ALL and AML) and antiangiogenic agents should be used in treatment of acute leukemia alone or in combination with standard chemotherapy to improve the curance rate.