الفهرس 
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Abstract
Objective: to evaluate the maternal and perinatal outcome of pregnancy in women with hepatic dysfunction. Methods: prospective analysis of 943 pregnant patients either recruited from certain rural areas or attending the antenatal care unit Mansoura University hospital ?high risk pregnancy unit? 26 cases were excluded as they did not complete follow up or missed from the study. 82 women with hepatic dysfunction were detected on the basis of presence one or more of the following, elevated serum SGOT , SGPT level > 40U/ml and or elevated serum bilirubin >2.5mgm/dl. Cases and control were followed through pregnancy by clinical, laboratory abdominal, Obstetric ultrasonography and color Doppler for portal vein. Pregnancy outcome either maternal or perinatal were compared to patients with normal current or past pregnancy (control) 376 cases. Results: among 943 pregnant patients 82 cases with hepatic dysfunction were recruited by incidence of 9.23% of cases. the commonest group with hepatic dysfunction was with preeclampsia either associated with HELLP. syndrome or not followed by hepatitis B. or C. The third in frequency is bilharzial patients, then combined diagnosis followed by patients with IHC and cases of Obscure diagnosis Vertical transmission of hepatitis C was 18.75% and for hepatitis B, 33.3%. USSP computerized system used for statistical analysis. Conclusion : The relatively high incidence of hepatic dysfunction among pregnant patients require multidisplinary team approach and a special care in a well equipped centers with all facilities Of intensive care unit, and incubators. Vaccination programs, other preventive methods must be implemented as a routine standard care of both mother and fetus . other extended metaanalytic multicentric researches for the our great dilemma especially of hepatitis C.