الفهرس 
Endometrieum receptivity
Definition, HistoryOnly 14 pages are availabe for public view
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Abstract
Introduction: The implantation process still constitutes the limiting factor to increase pregnancy rate in assisted reproduction. It can be improved by the improvement in the hatching process of the embryo through assisted hatching procedure. Assisted hatching is a laboratory procedure whereby the zona pellucida around the embryo is weakened to help the process of hatching. It can be done at day 2 or 3 for the 48 cell embryo can be done also for the blastocyst at day 6 after fertilization. Assisted hatching (AH) is adopted to improve implantation by mechanically facilitating the hatching process especially if ZP is either thick or hard. Assisted hatching help to overcome the asymmetry between the window of implantation and the hatching time of the embryo. Assisted hatching may be done by many methods: Mechanical method Chemical method Biochemical method Piezoelectric method Laser method Disadvantage of assisted hatching: 1) High cost. 2) Damage of the embryo. 3) Damage of embryo during transfer. 4) Congenital malformation. 5) Thermal injury to DNA of embryo. 6) Increase incidence of monozygotic twinning (MZT). 7) Increase incidence of ectopic pregnancy. Conclusions: Some studies reported a significant increase in the pregnancy and/or implantation rate in all patients but most of the publications reported significant improvement in patients with poor prognosis. On the other hand, third group of publication reported nonsignificant improvement in the patient with poor prognosis.