الفهرس 
Illtroduction & Ai”, ojtlle workOnly 14 pages are availabe for public view
 |  | from | 134 |  |  |
| | | from | 134 | | |
Abstract
Introduction: Endothelin1 (ET1) is a member of a family of potent vasoactive peptides it increases in various vascular and autoimmune diseases which i usually associated with Raynaud?s phenomenon (RP) so the aim of the present work is too study the relation ship between ET1 and vascular dysregulation in some collagen vascular diseases and its relation to their activity. Subjects & Methods A group of systemic lupus , a group of rheumatoid arthritis and a group of scleroderma patients as well as a healthy control group were examined plasma ET1 levels were compared in each patient group to control group and the relation between vascular dysregulation, ET1 and diseases activity score were analyzed. Results Plasma ET_1 is higher in rheumatoid arthritis, scleroderma patients than control group and to lesser extent in systemic lupus patients. It correlates with the disease activity. However, it not related the existence or extent vascular dysregulation. Conclusion: The role of ET1 in vascular dysregulation can?t be completely overruled by the present study farther investigations may look in to this relation relying on time course studies provocative methods and sensitive equipments for assaying minor degrees of vascular dysregulation.