الفهرس 
Part one:Overview of colorectal cancer
Hepatic resectionOnly 14 pages are availabe for public view
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Abstract
Colorectal carcinoma is the third most common cause of cancer death and two-thirds of all patients with colorectal cancer will develop metastasis to the liver and other organs in their life span. Curative resection is possible in less than 25% of those patients with disease limited to the liver and the 5-year survival achieved is 30–40%. The rationale for HAI is to expose the metastases to high chemotherapy concentrations while minimizing systemic toxicity. The principle of is based on tumour destruction by applying heat (radiofrequency ablation, microwave coagulation therapy, interstitial laser phototherapy and high-intensity focused ultrasound) or cold (cryotherapy) or by chemical tumour destruction (ethanol injection). Use of chemotherapy in patients with metastatic disease prolongs survival and enhances quality of life in comparison to palliative care alone. Whole liver radiation produces temporary palliation of pain for patients with hepatic metastases. The objective of gene therapy for the treatment of cancer is to kill tumour cells but preserve normal tissue; therefore, the ideal gene therapy agent will be targeted for specific transduction of tumour cells and have specificity in its cytotoxic action.