الفهرس 
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Abstract
Background: Anesthetic agents have been shown to potentiate neuromuscular blocking effects of rocuronium by prolongation of duration of action & decrease dose requirements. Aim of the study: The purpose of this study was to evaluate neuromuscular blocking characterstics of rocuronium during sevoflurane versus isoflurane anesthesia. Methods: Thirty patients (2555 years old) of either sex were included in this study and classified into 2 equal groups. Anesthesia induced with sleeping dose of propofol 2mg/kg and intubating dose of rocuronium 0.6 mg/kg. anesthesia was maintained in 1st group by: N2O/O2:2/1 and isoflurane 0.51%, while in 2nd group, anesthesia was maintained by N2/O2: 2/1 0.51.5% sevoflurane. Controlled ventilation with incremental doses of rocuronium (1/5 initial dose) was used. Results: There was signification prolongation in duration of action of rocuronium with decrease in effective doses needed in sevoflurane group when compared with isoflurane group. Conclusion: According the these results, sevoflurane anesthesia potentiates the effect of rocuronium compared with isoflurane, so the dose of rocuronium may have to be adjusted during sevoflurane according to neuromuscular monitoring responses.