الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
β-thalassemia is a major public heath problem; It is the most commonchronic hemolytic anaemia in Egypt. This study was done in an attempt to evaluate the presence of hemostatic defects in thalassemic children and its explanation, which may be helpful in preventing and/or treating them and hence decreasing the morbidity and mortality. This study was carried out in Clinical Pathology Department; Pediatric University Hospital (Mansoura University Hospital). This study was conducted on 20 thalassemic children and 15 healthy control with matched age and sex with thalassemic group. Both cases and control were subjected to the following; 1- Detailed history taking as regard • History of thrombotic events • Family history of thrombosis • Drugs alter hemostatic functions • Number of previous blood transfusions 2- Complete clinical examination 3- liver function tests. 4- Screening tests including: • Complete blood picture (C.B.C) • Prothrombin time (PT). • Activated Partial Thromboplastin time (APTT) • Fibrinogen concentration 5- Specific tests including: • Anti-thrombin III (ATIII) • Thrombin-anti-thrombin complex (TAT) • Activated protein C resistance sensitivity ratio (APCS-R) .