الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The potential beneficial or adverse effects of apoptosis on sepsis are unknown. Apoptosis could be beneficial to the host by eliminating many of the lymphocytes that produce proinflammatory cytokines. Among several transcriptional regulatory factors involved in immunoregulatory genes expression, NF-kB acts at a critical step for directing the transcription of many pro-inflammatory genes in animal models of inflammatory disease, measurement of NFkB activation may help in predicting the outcome of sepsis. CD11b is an important adhesion molecule modulating the transendothelial migration of circulating polymorphnuclear granulocytes into the inflammatory region and also important during inflammatory response and as a diagnostic marker in early onset sepsis. The current study compromised critically ill patients (18 males, 33 females), their age ranged from 2 years to 10 years, they were selected consecutively from patient admitted to Pediatric Intensive Care Unit of Mansoura University Children Hospital. The recruitment of cases extended over a period of time between December 2001 & April 2003. It was concluded that: 1. NFKB and CD11b were found to be high in all patients with sepsis, being higher in MODS group than all other groups. 2. Daily determination of NF-kB and CD11b should be made because the peak value is the most informative. 3. The expression of BCl2 was significantly low in all studied patients with significantly lower level in MODS group compared to others indicating that BCl2 gene protects a wide variety of cell types from undergoing apoptosis in response to infection. 4. NFKB, BCl2, CD11b expression are related to the severity as well as the outcome of systemic inflammation and if repeated in the 1st few days of sepsis may have a more prognostic meaning than if done once at the beginning of the disease. 5. These findings might be helpful in planning strategies to safely reduce the morbidity and mortality in patients with severe sepsis.