الفهرس 
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Abstract
Background: Adhesion molecules on lymphocytes and their counterparts on endothelial cells determine the specificity of lymphocyte recirculation and homing. Chronic lymphoytic leukemia (CLL) is a neoplastic disease characterized by the accumulation of small mature-appearing CD5+ B lymphocytes in the blood, marrow, and lymphoid tissue Aim of work: The aim of the present study is to analyse the expression of some of the adhesion molecules regulating lymphocyte traffic, in series of patients diagnosed as chronic lymphocytic leukaemia. We also wish to correlate the findings with various clinical and laboratory features, and to assess their prognostic value. Methods: This study comprised 32 patients with CLL besides 15 apparently healthy individuals as a reference group. The patient groups comprised 17 males and 15 females diagnosed as CLL. Their ages ranged from 39 to 55 years. The patients and reference groups were subjected to the following: (1) Detailed history taking, complete clinical examination as well as the following investigations: CBC, serum LDH. (2) Immunological investigations including: CD5, CD19, CD54, and CD62L. Results: From the present study, one can conclude the following: A) As regards hematological findings: ” There were significant statistical differences in lymphocytic counts and WBCs between refractory and responding groups. B) As regards biochemical findings: ” There were significant statistical differences in serum LDH between patient and reference groups. C) As regards immunological findings: ” Significant statistical differences in the expression of CD5, CD19, CD54 and CD62L between patient and reference groups. ” No significant statistical differences in the expression of CD54 and CD62L between refractory group and responding group. Conclusion: we can conclude that, the surface expression of ICAM-1 and L-selectin is higher in patients with CLL than the normal subjects. However, among patients with CLL, ICAM-1 is expressed in a minority of cases and L-selectin is expressed in the majority of cases. The expression of ICAM-1 and L-selectin in patients with B-CLL are variable and poorly correlated to the clinical and hematological parameters.