الفهرس 
introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Introduction: Lymphomas are heterogeneous group of neoplastic disease, resulting from clonal proliferation of mature B or T lymphocytes. Despite the recent advances in chemotherapy, the cure rates remains faraway from our expectations. A number of prognostic factors, has been identified, in order to classify the disease. Age at diagnosis, Hb concentration, ESR, 2 microglobulin and serum LDH are well know prognostic factors. Aim of work: The aim of this work was to assess the prognostic significance of CA125 in patients with NHL, and to correlate it with the already known prognostic factors. Methods: This study was carried out at the Haematology/Oncology Unit, Department of Medicine, Faculty of Medicine, Mansoura University. Cases were selected from the out-patient clinic, Mansoura University Hospitals. This study was conducted on 40 adult individuals, aged from 15 to 75 years and divided into two groups: Group I: 10 apparently healthy individuals of matched age, and sex served as a control group and Group II: 30 adult patients (17 females and 13 males) with age range 15 - 75 years, histopathologically diagnosed as NHL. Patients and control group were subjected to the following (Detailed history taking - Complete clinical examination - Laboratory investigations such as CBC, ESR, serum albumin, serum bilirubin, AST, ALT, Serum creatinine, LDH and specific investigations such as serum CA125 level by ELISA technique). Results: Our results revealed the following: ” After 4 cycles of chemotherapy, patients with CR had lower ESR, LDH and CA125, when compared to the PR and no response group. ” High ESR, LDH, CA125 and low Hb concentration in patient with advanced stage of the disease and poor response to chemotherapy. ” Patients with high CA125, LDH, ESR levels before chemotherapy, and in whom the levels are not reduced gave no response to chemotherapy. ” Marked reduction in the CA125, LDH, ESR were observed in the CR group. ” In our study, CA125 correlated positively with age, IPI and 1st ESR. Before treatment. And with stages IPI, ESR1, ESR2 and LDH and negative with age, Hb concentration after treatment. Conclusion: CA125 is reliable biological marker that can be used for the staging and restaging of NHL’s patient, indicating serosal involvement and advanced stages. Also, it is a reliable prognostic factor, for monitoring the response to therapy, and can be combined with the other prognostic factor.