الفهرس | Only 14 pages are availabe for public view |
Abstract Acute myocardial infarction is a serious medical emergency resulting in most cases from complete thrombotic occlusion of infarct-related coronary artery (Fuster et al., 1992). Several studies have shown that thrombosis and inflammation play an important role in the pathogenesis of ischaemic heart disease. In particular, tissue factor is responsible for the thrombogenicity of the atherosclerotic plaque and plays a key role in triggering thrombine generation (Falciani et al., 1998). Also, IL- I 0, a proinflammatory cytokine, has been implicated to play an important role in the development and The aim of this work was to assess serum IL- I 0 and plasma TF concentrations in AMI patients and in hypertensive, cigarette smokers and postmenopausal females as high risk groups for AMI. This study was carried out in the Department of Medical Biochemistry, Faculty of Medicine, Mansoura University. The present study included 68 subjects with age ranged from 40 to 65 years. They were divided into 5 groups; acute myocardial infarction, hypertensive, cigarette smokers, postmenopausal and healthy control groups. All subjects were subjected to thorough history taking, clinical ,examination and routine laboratory investigations. Blood samples were collected by clean venipuncture and divided into two portions. One portion was collected on 3.8% tri-(97) |