الفهرس 
Introduction and aim of the work
Incidence of Bladder CancerOnly 14 pages are availabe for public view
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Abstract
The treatment of invasive bladder cancer should be focused upon control of local disease as well as metastatic disease. Of. Those cancers that are muscle invasive transitional cell carcinoma on initial evaluation, 50% are associated with distant micro metastases at the tine of presentation. Therefore, localized therapy alone (Radical cystectomy or radical radiotherapy) may 110t be curative and combination chemotherapy may be required in an effort to control metastases. The aim of this work is to compare the effect of combined chemo radiation versus radical cystectomy in treatment of invasive transitional cell carcinoma of the bladder. The study has been started since December 1997 to December 2000, 70 patients with invasive tn1l1sitional cell carcinoma of the bladder T2-3 NoMo attending urology center were included in the trial, 35 patients in group I (radical cystectomy) and 35 patients in group II (combined chemo radiation). Patients 111 chemo radiation group underwent transurethral resection of the tumor followed by 2 courses of CMV then whole pelvic irradiation at dose of 40 Gy/5 weeks /25 treatments with concomitant 5-fluorouraciJ during l S ( and 5th week of radiation treatment at dose of 200 mg/m2/5 days followed by 25 Gy/3 weeks /15 treatments localized irradiation.