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Abstract The present study was carried on 90 male albino rats. They were lvided into 9 groups, each consisting of 10 rats to study the influence of igh-fat and high-carbohydrate feeding, stress and different hormonal actors involved in the stress reaction on hepatic insulin extraction. In each group of this study, the levels of glucose, FF As, insulin, C-peptide were measured in arterial blood, portal venous blood, and hepatic venous blood from the fasting rats. From these data, insulin delivery and FFAs delivery to the liver, hepatic extraction of insulin and FFAs, and hepatic glucose production were estimated. Groups of the present study included: 1- Control group: Water and usual diet consisting of bread, milk, and vegetables were allowed to rats of this group. 2- High-fat diet group: Rats of this group were fed a diet composed of 200/0 carbohydrate, 200/0 protein, and 600/0 fat for 3 weeks. 3- High-Carbohydrate diet group: The rats fed a diet composed of 60% carbohydrate, 20% protein, and 20% fat for 3 weeks. 4- Stress group: Rats were housed in two cages, each containing 5 males with one female for 24 hours. 5- Adrenaline group: Adrenaline was injected intramuscularly in a dose of 3 ug/kg daily for one week. |