![]() | Only 14 pages are availabe for public view |
Abstract Vascular complications comprise one of the most frequent complications in diabetes and may be a leading cause of increased mortality in, these patients. Many theories may postulate the etiology of these vascular complications (Magill and Danaberg, 1996 Vascular endothelium plays a dynamic role in the regulation of various process for example, hemostasis, fibrinolysis, vasomotor control and vascular permeability (Pearson, 1993). All of which may be relevant to the pathogenesis of vascular complications in diabetes mellitus,, therefore markers of endothelial dysfunction are candidate risk indicators for the development of such complications (Colwell et al 1992 Von Willebrand factor and / or thrombomodulin may serve as such markers of endothelial disruption or activation (Williamson et al., 1993). S05 we planned this work to clarify the role of Von Willebrand factor and thrombomodulin as markers of endothelium malfunction to predict silent vascular complications in diabetes mellitus. |