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Abstract Magneti~ resonance imaging is considered the highly sensitive and effective radiological modality in the diagnosis of most of neonatal hypoxic-ischemic brain lesions as it provides the best anatomic resolution of hypoxic-ischemic brain lesions and demonstrates the stages of normal brain myelination. MRl is .more sensitive than either CT scan or ultrasound in detection of cerebral ischemia especiallY when the lesion is in the first 72 hours after the ischemic insult, whether accompanyinea with hemorrhage or not. MRl is the imaging modality of choice in demonstrating parasagittal cerebral injury as well as selective cortical neuronal necrosis which are difficult to be visualized by both CT scan or ultrasound as the lesions are too peripherallY located to be visualized easily and the interpretation of changes on CT scan may be difficult during the neonatal period. MRl can demonstrates periventricular stricking abnormalities and periventricular microcavitations which are demonstrated in the early stages of periventricular leukomalacia while CT scan and ultrasound often provide ambiguous results during this period. Magnetic resonance imaging as well as ultrasound are considered to be the imaging modalities of choice for demonstrating gen:ni1lal matrix hemorrhage. However, |