الفهرس 
Aim of the workOnly 14 pages are availabe for public view
 |  | from | 173 |  |  |
| | | from | 173 | | |
Abstract
A causal relationship between excessive intake of NSAIDs and renal, hepatic and gastric lesions is now widely accepted. Many investigators have proved that both the therapeutic properties as well as the side effect of these agents are related to blockade of prostaglandin production. The present work aimed to uncover the possible protective effect of calcium channel blockers upon the untoward effect of NSAIDs (aspirin and diclofenac sodium) on chronic use. The effects of the previously mentioned drugs were investigated on differe~t renal function paramete~s including senun urea and creatinine as well as associated renal .. histopatholo,gical changes. Also, on liver fimction (SGPT and associated hepatic histopathological changes), and gastric effects (histopathological changes). In our study oral administration of verapamil alone for :2 months although it increased PGE2 level in urine of rats yet it did not induce any significant effect on kidney, liver and stomach (urea~,creatnine, SGPT and histopathological examination). Both aspirin and diclofenac administration orally in a dose of 500 mglkglday for 5 and 2 months respectively, induced marked decrease in pGE 2 in urine of rats and marked deterioration of renal and hepatic functions (urea, creatinine and SGPT). This was accompanied by marked histopathological changes in kidney, liver and stomach, which revealed .