الفهرس 
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Abstract
Varipus studies from different parts of the world have showed impairment hypersensitivity reactions in bilharzial hepatic fibrosis. This is characterised by an increase in B lymphocytes and a decrease T lymphocytes. It was found that, in human schistosomias is only a proportion individuals develop post-schistosomal liver fibrosis. The aim of this work is to try to distinguish the abnormalities of T ,smphocyte subpopulat ions in pat ients with chronic schistosomiasis and its pos- ible relation in development of bilharzial hepatic fibrosis. his Study comprised 39 bilharzial patients with pure intestinal schistomiasis ,for more than two years and recieved no antibilharzial or medical treatment that may affect immunologic state. All patients were subjected to thorough clinical examination, stool and urine analysis, proctosigmoidosCoPY and rectal snip, indirect haemagglutination tests complete blood picture, liver function tests and liver biopsy was done to cla¬rify if there is liver fibrosis or not; and to exclude any pathological condition in the liver. According to the results of liver biopsy our patients were classified into 2 groupS: 1- Fibrotic group: included 19 patients, 14 males and 5 females with pure intstinal schistomiasis and were having hepatic fibrosis. Their ages ranged from 7-14 years. 2- Non fibrotic group: include 20 patients, 12 males and 8 females vlith pure intestinal schistcsomiasis and without liver fibrosis. Their ages ranged from 7-14 years. In addition, a third group of 60 normal controls of matched age and sex was included in this study. Exclusion of bilharzial infestation in control group was based on thorough clinical examination,urine, stool examination, proctosigmoidosCOPY with rectal snip and indrect haemagglutination tests.