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العنوان
Serum apolipoproteins A and B in children with nephrotic syndrome /
الناشر
Samaa Sami Mohamed Eid,
المؤلف
Eid, Samaa Sami Mohamed.
هيئة الاعداد
باحث / سماء سامى محمد عيد
مشرف / هدى احمد الدمياطى
مشرف / اقبال محمد ابوهاشم
مشرف / أشرف محمد عبدالباسط
الموضوع
Nephrotic syndrome-- children.
تاريخ النشر
1997.
عدد الصفحات
118 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/1997
مكان الإجازة
جامعة المنصورة - كلية الطب - Department of pediatrics
الفهرس
Only 14 pages are availabe for public view

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from 144

Abstract

Serum total cholesterol, triglycerides, LDL-C, HDL-C, apo Band apo A-I were studied in 29 patients with nephrotic syndrome. Their ages ranged from 1.2-12 years; 22 were males and 7 were females. In addition, 12 healthy children matching the patients as regards age and sex were studied. The patients were dividied into 2 groups: , Group A: Consisted of 20 patients in relapse. Group B: Consisted of 20 patients in remission. 11 patients were studied serially in the 2 stages. Serum concentration of total cholesterol, triglycerides, LDL-C and apo B were significantly elevated, while serum levels of HDL-C and apo A-I were insignificantly lowered in relapsing nephrotic patients compared ; to control. Patients presenting during the 3rd attack had the highest levels of serum apo B as well as serum apo B containing lipids compared to control and patients during the 1 st or 2nd attack. No significant difference ,was noticed in serum apo A-I levels between patients when grouped by the order of attacks. Remission of nephrotic syndrome was associated with significant reduction in serum levels of apo B as well as apo B containing lipids, meanwhile serum apo A-I increased to normal levels. Hypoalbuminemia may be responsible for these changes in lipid metabolism. During remission, serum total cholesterol, triglycerides and LDL-C were still higher than control, while serum HDL-C, apo Band apo A-I did not significantly differ from control.