الفهرس 
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Abstract
Herpetic Keratitis is a major cause of corneal blindness, l Icrpcx simplex virus (HSV), the causative agent belongs to the herpes virus group. There are two types: HSV -I and IISV -2. Although hoth types affects the eye, yet type-I is more common, While, type-2 is more resistant to antiviral drugs. HSV keratitis may be epithelial and / or stromal keratitis. Also.it may be indolent and trophic ulceration or stromal scarring and oedema. Herpetic corneal ulcer may present as dendritic, ameboid or marginal, and this could be combined with stromal ulceration. The first anti - viral drug was introduced. by kaufman in 1962 and was called iodoxyuridine. ’I11en the other drugs became available in the subsequent years. These drugs were divided into two group the first is non-selective drugs, which include iodoxyuridine, vidarabine, cyterabine and trifluoridinc. The other group which represented the thymidine - kinase specific drugs, which include acyclovir and bromovinyldeoxyuridine . There is certain limitations and failure of these drugs. The most important of which is the epithelial and ocular surface toxicity from long lise. These is together with the presence of resistant strains to these drugs . The concept of treatment resistance or clinical resistance has been proposed in the situation where an ulcer rai Is to heal with apparently adequate treatment with one antiviral drug. hut responds well when another drug or other modality of treatment is used.