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Abstract Hepatitis represent the most senous liver disease encountered in pregnant women, especially viral hepatitis which is the most common cause of jaundice during pregnancy. Hepatitis C virus infection among pregnant women, with its risk for maternal fetal transmission, represents a public health issue of sufficient magnitude to be investigated. This study comprised 767 pregnant women who were admitted to Obstetric Department, Mansoura University Hospital and screened for anti-HCV antibodies, HBsAg and anti-HI V antibodies. Pregnant women positive for anti-HCV antibodies were subjected to history taking, complete physical examination, and investigation for detection of HCV¬RNA in the serum by RT-PCR. Neonates of women positive for HCV¬RNA were tested for HCV-RNA using RT-PCR. Liver function tests were done for women positive for anti-HCV antibodies and for neonates of women positive for R T -PCR. In our study, out of 767 pregnant women, the prevalence of anti¬HCV antibodies by 2nd generation ELISA was 13.69%. In comparison 2.35% were HBsAg positive indicating that the prevalence of hepatitis B |