الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
The major problem in the management of epileptic patients during pregnancy is the possibility that certain antiepileptic drugs may induce fetal abnormalities. However, controversy still exsists regarding the potential teratogenicity of these drugs. The present work was carried out to evaluate the mutagenic and teratogenic potential of some commonlY used antiepileptic drugs. This was achieved through a two parts prospective study: a human part and an experimental part. The human part of this study r~as conducted to investigate the effects of administration of the antiepileptic drugs: phenytoin sodium, carbamazepine. phenobarbitone sodium, clonazepam and sodium valproate on human chromosomes. Seventy-two recently diagnosed and previouslY untreated epileptic patients in addition to ten normal and healthy persons (controls) constituted the material of this study. Every patient was treated with one of the antiepileptic drugs, in its therapeutic dose, as follows: 1- Nineteen patients were treated with phenytoin sodium. 2- Seventeen patients were treated with carbamazepine.