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Abstract In the present work we aimed to carry out a comprehensive histological and histochemical study of the adrenal medulla of adult male albino rats. special care was given to the methods that discriminate between the adrenaline and noradrenaline secreting cells. The ninety adult male albino rats used throughout our work were classified into three groups: The first group included the normal rats. The second group . 0.05 mg/gm. body weight tranylcypromine daily for one week. The third group included rats injected with 0.025 mg/gm body weight of chlorpromazine daily for one week. The adrenal medulla of control adult male albino rats was formed of rounded groupS or short ords of chromaffin cells with blood capillaies ~nd sinusoides in between them. Thin connective tissue partitions were seen within the adrenal medulla in haematoxylin and eosin stained sections. The chromaffin cells appeared basophilic, ovoid or polygonal in shape with eccentrically located large vesicular nuclei. Mallory stained sections revealed collagen fibres encircling the groupS of chromaffin cells and surrounding the venous branches. |