الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 174 |  |  |
| | | from | 174 | | |
Abstract
Type IDDM is complex, multifactorial disease. The susceptibility to develop type I was f irst f ound associated with HLA class I molecules B and B Later-, more rong ly with class II molecules DR - and DR Recently type I susceptibility was found to be strongly associated with some DO genes. So, we planed this work to evaluate the DOA 1 and DOB I polymorphism in IDDM patients their families. We are hopping to demonstrate the contribution of the genetic marker in the predisposition to IDDM to achieve this aim, we studied 10 families having at least one member suffering from IDDM type 1. and 14 age and sex matched member aS control with a total number of 53 individual ( ’’I’ male and 41 female). The number of patients were studied members were divided into 4 gi-oups (patient, parent offspring and control).Every one was submitted to the following thorough history taking with special stress on family history and consangunity, and determination of HL.A class 11 DO antigen by molecular biologic technique (S.S.D. method).