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Abstract Inhibitory nonadrenergic noncholinergic (iNANC~ neural responses that are bronchodilator pathway in human airways and have attracted considerable interest,particulary since their function may be defective in Asthma. Mechanisms of iNANC have been demonstrated in human airways in vitro by EFS. The nature of the neurotransmitter is still debated,although there is some evidence that VIP may mediate these effects.recently evidence has suggested that nitric oxide (NO) may mediate a large component of iNANC response.particently available neuronal konckout mice (nNOS-/-) mice provides rticulary useful model for evaluating the relative importance as a transmitter in the airways and other sites. We have, efore, compared tetrodotoxin-senstive relaxations of tracheal ents from nNOS knockout and control wild mice to electrical stimulation (EFS) and to VIP and also their responses to choline results of the present study demonstrates stronger contraction the tracheas from nNOS knockout mice to methacholine than in rol mice which was most probably because of the absence of the xant effect on neuronal nitricoxide In the presence of nergic and cholinergic receptor blockade, EFS (at 60 V for 2. |