الفهرس 
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Abstract
The aim of this work is to study the value of some biochemical markers as superoxide dismutase, catalase, glutathione peroxidase, some trace elements such as (iron, zinc, manganese, selenium and copper), serum Eselectin and Creactive protein and using them for the early detection of pediatric septecmia which was proved by positive blood culture and the causative organisms were identified and tested for antibiotic sensitivity. Thirty patients were included in this study ranged in age from one month to twelve months and eleven healthy controls were chosen. Two blood samples were withdrawn, one on admission and the other forty eight hours after admission where blind antibiotic therapy and intravenous fluids were started and the following results were obtained: 1 depletion of the levels of red blood cell supperoxide dismutase, whole blood glutathione peroxidase and the elevation of serum catalase on admission and 48 hrs after admission and they were dependent on the type of blood culture isolated organism except whole blood glutathione peroxidase on admission. 2 Nonsignificant decrease in the serum levels of iron, zinc and selenium while manganese was significantly increased and copper was nonsignificantly increased. They were independent on the type of blood culture isolated organisms. 3 The levels of Eselectin and Creactive protein were significantly elevated on admission and 48 hrs after admission. Only serum Eselectin was dependent on the type blood culture isolated organism while Creactive protein was independent. from this study we can conclude that: SOD, serum catalase, Eselectin and CRP can be used as biochemical markers for early detection of pediatric septicemia but the trace elements iron, zinc, selenium and copper are of little importance although manganese was significantly elevated in those patients.