الفهرس 
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Abstract
??Diabetes mellitus is an important risk factor for atherogenesis. It is well established now that platelet contribute to the pathogenesis of ACS not only by promoting thrombus formation but also by stimulation of an acute inflammatory response within the atherosclerotic plaque. Upon activation, platelets express Pselectin on their surface and through ligation with its ligands on monocyte/macrophage, Pselectin has the potential to enhance the activation of the transcriptional factorKB, a factor required for expression of chemokines, tumour necrosis factor (TNF ) and several other gene products playing a key role in inflammation. This inflammatory interaction between platelets and leucocytes, also involving endothelial cells may represent a vicious circle playing a pathogenic role not only in the chronic atherosclerotic process but also in triggering acute coronary syndromes. ??We found that, Pselectin levels were significantly higher in diabetic patients compared with nondiabetic control subjects and in diabetics with CAD than in diabetics without CAD. 0Also, the levels were higher in group of patient with AMI than those with unstable angina group than those with stable effort angina. ??The measurement of soluble Pselectin levels may represent a marker of platelet activation and their tendency for intracoronary thrombus formation, therefore Pselectin levels may help to understand the pathophysiology of ACS.