الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The study conducted on 50 cases with proven fascioliasis. Another 10 treated Fasciola cases, 50 Schistosomiasis mansoni patients and 50 healthy individuals were also included. The patient?s full history was taken and clinical examination was done. They all underwent stool examination by kato smear and simple sedimentation method. Data of complete blood picture, ultrasonography imaging and liver function tests were also evaluated. ELISA using ES antigens of adult Fasciola gigantica worms was done to detect total IgG, IgG1, IgG4, IgM and IgA antibodies in the sera. In addition salivary IgA and fecal IgA were also evaluated. ELISA was sensitive and specific. Fascioliasis was accompanied by elevation in various immunoglobulins classes including IgM, IgG, IgA, IgG1, IgG4, salivary IgA and fecal IgA. However all immunoglobulins classes were reduced in treated cases. The most specific and sensitive immunoglobulins in the diagnosis of human fascioliasis were IgG4 and IgA. Also the the detection of antiFasciola salivary IgA and fecal IgA could be a feasible and easy sensitive method for the diagnosis of human fsacioliasis, that could be used in future epidemiological studies.