الفهرس 
MENIERE AND SURGICAL MANAGEMENTOnly 14 pages are availabe for public view
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Abstract
Background: There is a specific pathway named vestibulo-cochlear pathway runs through the inferior vestibular nerve to cochlea. vestibular neurectomy (V.N) is a well-establishedprocedure that is performed to control intractable Meniere disease. However, the function and the histopathological changes of the cochlea that could be occurred after vestibular neurectomy were not fully studied.
Objectives: Experimentally test the effect of vestibular nerve neurectomy on the function and histopathology of the cochlea.
Subjects and methods: The study was conducted on 20 healthy male adult pigmented guinea pigs (Cavia porcellus). First, each animal was tested with Distortion Product Otoacoustic Emissions (DPOAEs) preoperatively then vestibular neurectomy (V.N) was performed on the right side through suboccipital modified retrosigmoid approach. After 8 weeks We tested the DPOAEs, then Guinea pigs were euthanized the cochlea of guinea pig was examined withlight microscope and transmission electron microscope to observe the outer hair cell count, and spiral ganglion cell density in the operated ear compared to contralateral non operated cochlea of the same guinea pig.
Results: A significant decrease in spiral ganglion cell density in the operated side in comparison with the non-operated sidewas observed. However, there was no significant difference in outer hair cell count or DPOAEs between the two sides.Additionally, lamellae appeared less compact and more disorganized, with gaps and irregularities in the myelin sheath on electron microscope.
Conclusion: The results suggest that vestibular neurectomymay affect spiral ganglion cell density but not necessarily outer hair cell count or DPOAEs, and the relationship between these variables is complex and could be frequency-dependent.