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العنوان
Neurological Complications and Cognitive Function after Pediatric Living Related Liver Transplantation/
المؤلف
Mohamed,Athar Abd Elhakim
هيئة الاعداد
باحث / آثار عبدالحكيم محمد
مشرف / توحيدة ياسين عبدالغفار
مشرف / سوزان عبدالرحيم الناغى
مشرف / أسماء وفيق عبد العزيز
مشرف / مها زكريا رمضان محمد
تاريخ النشر
2024
عدد الصفحات
143.p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
4/4/2024
مكان الإجازة
جامعة عين شمس - كلية الطب - Pediatrics
الفهرس
Only 14 pages are availabe for public view

from 143

from 143

Abstract

ABSTRACT
Common neurological complications following liver transplantation include seizure, encephalopathy, posterior reversible encephalopathy syndrome (PRES), central pontine myelinolysis (CPM), tremors Cerebral atrophy, meningitis, hemorrhage, cerebrovascular infarct, cerebral abscess, cognitive decline, peripheral neuropathy, and sinus thrombosis.
Complications may be associated with several pathogenic factors such as a poorly functioning graft, intracranial hemorrhage, cerebral infarctions, infections, or immunosuppressive drug toxicity. Most of these cases present within the first month after the LRLT.
Current research suggests that liver transplanted children are at higher risk for developing cognitive deficits compared to the age-matched normal population
With consideration that we did not access cognitive function before liver transplantation. In a previous study that included 64 pediatric patients after LRLT. Children who underwent LRLT performed significantly worse in three of four cognitive domains as well as in the Total Intelligence Quotient (Total IQ).
In another pervious study they have provided novel evidence that there is some neurocognitive impairment in children with biliary atresia before liver transplantation and that liver transplantation may improve the neurocognitive functions of these children. Postoperative neurocognition was closely correlated to the preoperative condition.