الفهرس 
CHRONIC SPONTANOUS URTICARIAOnly 14 pages are availabe for public view
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Abstract
Chronic spontaneous urticarial (CSU) is defined as the appearance of wheals and /or angioedema for a total duration of six weeks or more , CSU is approximately 15–25% of the population , affecting the quality of patients’ life. This study aimed to evaluate interleukin 13 (IL-13) versus transforming growth factor Beta (TGF-ß) as a prognostic factor in the management of CSU. The current study was designed as a cohort study, including 40 patients with CSU recruited from the allergy and immunology outpatient clinic at Ain Shams University Hospitals from 2022 and 2023. Also, 25 healthy controls who were group-matched with patients for age and sex recruited from healthy relatives of patients, hospital workers and nursing staff were included in this study. Serum IL-13 and TGF-ß were measured by an enzyme linked immunosorbent assay (ELISA) at baseline, six-month follow-up after receiving subcutaneous allergen immunotherapy. the mean of serum IL-13 level at the start was 30.6 pg/ml and after 6 months was 22.1 pg/ml, which was significantly higher in CSU group than in Control group which was 4.7 pg/ml. the mean level of TGF-ß at the start was 106.6 ng/ml and after 6 months was 114.9 ng/ml, which was significantly higher in CSU group than in Control group 59.1 ng/ml. After which we concluded that IL-13 had significant almost perfect diagnostic performance than TGF-ß in differentiating chronic spontaneous Urticaria cases from control. Also, IL-13 had non-significant low prognostic performance , while TGF-ß had significant moderate prognostic performance in predicting partial/ complete response from non-response.