الفهرس 
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Abstract
The present study was established to estimate cefquinome residual concentrations and pharmacokinetics in mullet fish using HPTLC. A total number of 40 apparently healthy mullet fish (Mugil Cephalus) with an average body weight of 750±50g were transported alive to 8 glass aquaria. Cefquinome sulfate (Cobactan® 2.5%) was given as a single intramuscular dose of 10 mg/kg body weight. At each sampling point (6, 24, 48, 72, 96, and 120 hours post-medication), serum, muscle, liver, and kidney samples were collected to assay cefquinome concentrations using HPTLC technique. The maximum concentrations were recorded in the following order: liver > kidney > serum > muscle. Cefquinome concentration in muscles decreased gradually to became under our detection limit (0.045 ng/mL) at 3 days (61.7 hrs) post-medication. At that time, cefquinome concentrations were still detectable in the liver and kidney and up to the end of the 5th-day post medication. Furthermore, the cefquinome withdrawal times were calculated to be 61.7, 105.6, and 90.5 hours in Mugil’s muscles, liver, and kidney respectively. Hence, cefquinome withdrawal time was estimated to be 3 days in mullet’s muscles after a single intramuscular dose of 10 mg/kg body weight under 24 ⁰C water temperature. If cefquinome will be used therapeutically in broader mullet, 2-3 intramuscular doses of 10 mg/Kg b.wt. with 2.5 days intervals should insure a sufficient MIC for most of bacterial pathogens.