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Abstract Normal aging is a process that possesses many effects on the morpho-functional characters of the brain and other organs of the mammalian body. Our study focused on clarifying the age-related structural changes that occurred in the brain of a large number of albino rats, as a good animal model, ranging from three over twenty-four months of age. These changes might play an important role in the occurrence of neurodegenerative disorders in the brain, particularly in senile rats. The work also aimed to understand the mechanism of aging and how it affected the macroscopic and microscopic morphometry of some brain structures. The present work was carried out on 60 apparently healthy laboratory albino rats of both sexes (with known dates of birth). The study concluded that ageing had a great impact on the macro- and micro morphometric measurements of some brain structures. Age- dependent changes also were also elucidated by light microscopy and transmission electron microscope. |