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Abstract β-thalassemias are a group of recessively inherited hemoglobi disorders characterized by reduced synthesis of β globin chains. Thalassemia constitutes the most common inherited recessive disorder associated with consanguinity, which is a common phenomenon in Egypt. Allo-HSCT is the only established treatment modality that provides a possibility of cure and considered cost effective compared with conventional therapy. Thalassemia patients as a result of persistent antigenic challenge from blood transfusions, generally represents with higher lymphocyte counts. Difference subsets of lymphocytes, including helper T cells. |