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Abstract Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent psychiatric disorders experienced by children. It was initially thought that attention-deficit hyperactivity disorder (ADHD) remits in all children. According to epidemiological studies, can be persistent and affect between 10 - 80% of adults (18–44 years), with at least one or more symptoms of ADHD. Comorbidity with ADHD is present among ∼75% of adults with this condition and includes several psychiatric disorders, including Substance Use Disorders (SUD) at rates reaching 15–45%. This cross-sectional analytical study was conducted among patients with substance use disorders and aimed to estimate the prevalence of adult ADHD among SUDs patients. This study was conducted at Department of Psychiatry and Addiction, Suez Canal Regional Hospitals, Ismailia, Egypt from July 2021 to Feb, 2022. The prevalence of ADHD according to ASRS was 22.5% among patients with SUDs. A total of 80 patients with SUDs were recruited in this study with the mean age 32.8± 6.9 years. Males represented 93.8% while females were only 6.2%. The majority of them completed secondary education (40%) and 27.5% were college/ institute educated. One quadrant of them were unemployed and nearly half of them were married. There was 26.3% had low SES, 55.1% had average SES and 17.8% had high SES. There was no statistically significant difference between ADHD and non-ADHD regarding socioeconomic data except for occupation. Higher percentage of unemployed were among ADHD group compared with |