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Abstract Schistosomiasis is still a major public health problem, affecting millions in tropical countries especially in Africa and about 236.6 million people required preventive treatment in 2019. More than 200,000 deaths per year are due to schistosomiasis in sub-Saharan Africa. It also accounts for over 1.8 million disability adjusted life years, the third highest global burden. In 2019, the world was affected by COVID-19 global pandemic, and many vaccines were developed to control this serious disease. The scientific and public health community must combat COVID-19, but not at the expense of ignoring research on acute and chronic parasitic infections, as well as their control and preventive programs. Coronavirus vaccine induces Th cell responses mainly with predominance of Th1 cells and less Th2 response, so the immune reaction of COVID vaccine may interact with the pathogenesis of acute and chronic schistosomiasis. The mRNA vaccine can serve as both immunogen and adjuvant, owing to the intrinsic immune stimulatory properties of RNA. Also, the lipid nanoparticle is an immune stimulant. The mRNA vaccine is the best alternative among all COVID vaccines because it shows no side effects, very effective, high potency, safety capacity for rapid clinical development, and potential for rapid low-cost manufacturing. |