الفهرس 
Epidemiology and pathophysiology of sepsisOnly 14 pages are availabe for public view
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Abstract
Abstract
Background: It is still challenging to identify people who are at risk for developing sepsis quickly and early. Heparin-binding protein (HBP) has been demonstrated a promising data that can be used as predictive qualities in identifying organ failure.
Methods: This prospective observational investigation of 55 adult patients who have been proven to have sepsis, and were hospitalized into the intensive care unit. By carrying out HBP, procalcitonin (PROCAL), C-reactive protein (CRP), Serum lactate, SOFA score on admission and after 72 hours and detecting 28-day mortality.
Results: Despite PROCAL and HBP were higher in survival than non-survival patients at day 0 (1010.32±341.72 vs 770.21±327.97, p=0.0112) (16.73±7.19 vs 13.19±7.26, p=0.077) respectively, It was significantly lower in survival than non-survival at day 3 (542.09±191.98 vs 995.00 ± 333.74, p =<0.0001) (9.03±2.92 vs 16.67±7.55 ,p =<0.0001) respectively. Our main marker HBP decreased significantly from day 0 to day 3 for survival patients with paired difference -7.69 ± 6.78 with p value <0.0001, while it is increased with non-significant value for non-survival patients with paired difference 3.48 ± 9.45 with p value 0.084. ROC analysis for mortality showed for HBP that AUC at day 0 was 0.323 (p= 0.025). At cut-off value of >15.5 ng/ml, sensitivity was 29.2%, specificity was 64.5%, while at day 3 was 0.831 (p= 0.000). At cut-off value of >9.5 ng/ml, sensitivity was 83.33%, specificity was 77.42%.
Conclusion: HPB showed a strong prognostic marker of mortality in ICU septic patients at day 3 more than day 0 with important value and trend.