الفهرس 
Definition of hyperlipidemiaيوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Hyperlipidemia is a medical term for abnormally high levels of fats (lipids) in the blood, which include cholesterol and triglycerides. Although hyperlipidemia can be inherited, it’s most often the result of lifestyle factors, including an unbalanced diet and too little physical activity. Hyperlipidemia has been shown to be a strong risk factor for coronary heart diseases indication. Hyperlipidemia is usually quite manageable, though, and these emergency events can often be avoided. The key is an early diagnosis and treatment plan to prevent its progression.
The plant Solenostemma argel (S. argel) belongs to the Asclepiadaceae family. It is a desert plant widely distributed in Egypt with common name ’Hargal’. The plant is widely used in traditional folkloric medicine as antispasmodic, anti-inflammatory and antirheumatic agent. Also, the whole plant is used in treatment of diabetes mellitus, hypercholesterolemia, jaundice, cough, cold and measles. It was described to alleviate gastrointestinal cramp, urinary tract infection and menstrual disturbance.
Argel is a rich source of indoline, alkaloids, steroids, and glycosides which possess antitumor and anticancer activities. Previous phytochemical studies showed that the leaves are rich in carbohydrates, potassium, calcium, magnesium, and sodium while low in fibers, protein, oil, ash, copper, manganese and lead.
Rats were randomly divided into two main groups.
The first group, negative control group (n = 6), fed standard diet only.
The second main group Hyperlipidemic rats (n=30).
Hyperlipidemic rats were divided into 5 sub-groups (6 rats each) according the following:
Sub-group 1: Hyperlipidemic rats fed on standard diet only,as a positive control.
Sub-group 2: Hyperlipidemic rats fed on standard diet with 1% of argel powder.
Sub-group 3: Hyperlipidemic rats fed on standard diet with 2% of argel powder.
Sub-group 4: Hyperlipidemic rats fed on standard diet with 3% of argel powder.
Sub-group 5: Hyperlipidemic rats fed on standard diet with 4% of argel powder.
During the experimental period, the body weight and feed intake were estimated weekly and general behavior of rats was observed.
The experiment will take 28 days, at the end of experimental period each rat weight separately then, rats are slaughtered and collect blood samples after 12 hours of fasting. Blood samples were centrifuged at (4000 rpm) for ten minute to separate blood serum, then kept in deep-freezer till using. Extracting the liver, spleen, kidney and heart, the following tests were conducted for histological examinations.
The obtained results could be summarized in the following:
1. Effect of argel as powder on body weight gain, feed intake and feed efficiency ratio of hyperlipidemic rats:
The highest value of body weight gain, food intake and feed efficiency ratio recorded for positive control group, while negative control group recorded the lowest value with significant (P≤0.05) differences.
For treated groups the highest body weight gain value recorded for 1% argel powder, while 4% argel group recorded the lowest value with significant (P≤0.05) differences.
The highest feed intake levels of treated groups recorded for 1% argel powder, while the lowest value recorded for 3% argel powder group with significant (P≤0.05) differences.
The highest FER levels of treated groups recorded for 1% and 2% argel powder, while the lowest value recorded for 4% argel powder group with significant (P≤0.05) differences.
2. Effect of argel as powder on relative internal organs weight of hyperlipidemic rats:
The highest relative liver weight value recorded for negative control group, while positive control group recorded the lowest value with significant (P≤0.05) differences. In case of treated groups, the highest value recorded for 1% argel powder group, while 3% and 4% argel powder groups recorded the lowest value with significant (P≤0.05) differences.
The highest relative heart weight value recorded for positive control group, while negative control group recorded the lowest value with significant (P≤0.05) differences. In case of treated groups, the highest value recorded for 3% argel powder group, while 2% and 4% argel powder groups recorded the lowest value with significant (P≤0.05) differences.
The highest relative lungs weight value recorded for negative control group, while positive control group recorded the lowest value with significant (P≤0.05) differences. In case of treated groups, the highest relative lungs weight of recorded for 2% argel powder group, while the lowest value recorded for 1% argel powder group with significant (P≤0.05) differences.
The highest relative spleen weight value recorded for negative control group, while positive control group recorded the lowest value with significant (P≤0.05) differences. In case of treated groups the highest relative kidney weight of recorded for 3% argel powder group, while the lowest value recorded for 1% argel powder group with significant (P≤0.05) differences.
3. Effect of argel as powder on serum triglycerides (T.G) and serum total cholesterol (T.C) levels of hyperlipidemic rats:
The highest value of serum T.C and T.G levels recorded for positive control group, while negative control group recorded the lowest value with significant (P≤0.05) differences.
For treated groups the highest value of serum T.C and T.G levels recorded for 1% argel powder, while 4% argel powder group recorded the lowest value with significant (P≤0.05) differences.