الفهرس 
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Abstract
Celecoxib, a NSAID drug, preferentially inhibits COX-2 enzymes. Numerous chronic conditions like osteoarthritis (OA), rheumatoid arthritis (RA), and chronic pain are treated with celecoxib, which is routinely administered for long periods of time (i.e., months to years), according to current estimates.
Fifty, apparently healthy, male albino rats weighing 200-230 gm, randomly divided into five equal groups; each of 10 rats. group 1: rats received no drug. group 2: rats received celecoxib (50 mg/kg/day, orally), for 30 successive days. group 3: rats received celecoxib (50 mg/kg/day, orally), and royal jelly (300 mg/kg/day, orally) for 30 successive days. group 4: rats in this group received celecoxib for 30 successive days, then rats were left untreated for another 30 days. group 5: rats received celecoxib and royal jelly for 30 successive days, then rats were left untreated for another 30 days.
The obtained results can be summarized as follows,
• Celecoxib administration at mentioned dose, did not cause gastric ulcers in male albino rats.
• Celecoxib administration at mentioned dose, caused hepatic, renal, and cardiac toxicity, with ameliorative effects of royal jelly. Celecoxib discontinuation significantly diminished the celecoxib-induced toxicity effects, and normal liver, kidney, and cardiac functions were regained in case of dual medications (celecoxib+RJ) discontinuation.
• Celecoxib administration at mentioned dose, caused a non-significant subfertility. An ameliorative effect of royal jelly against celecoxib-induced infertility. Celecoxib discontinuation significantly diminished celecoxib-induced infertility, and a normal fertility profile was regained in the case of dual medications (celecoxib+RJ) discontinuation.
• Celecoxib administration at mentioned dose, caused oxidative stress in male albino rats, with ameliorative effects of royal jelly against celecoxib-induced oxidative stress. Celecoxib discontinuation significantly diminished the celecoxib-induced oxidative stress effects, and normal oxidative enzyme levels were regained in the case of dual medications (celecoxib+RJ) discontinuation.
• Celecoxib administration at mentioned dose, induced an apoptotic effect in male albino rats in liver, kidney, heart, and testis with ameliorative effects of royal jelly against the celecoxib-induced apoptotic effect. Celecoxib discontinuation significantly diminished the celecoxib-induced apoptotic effect, and normal apoptotic/anti-apoptotic genes expression was regained in the case of dual medications (celecoxib+RJ) discontinuation.