الفهرس 
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Abstract
Beta-thalassemia is major public health problem in Egypt. The incidence of thromboembolism in thalassemia patients is approximately 10 times higher than normal population. However, decreased platelet aggregation in β-thalassemia patients which presented by bleeding manifestations was reported. The net clinical outcome depends on the balance between the prothrombotic and antithrombotic pathways. Cross-sectional study on 98 β-thalassemia patients. Coagulation screen, D-dimer, protein C, antithrombin III, ferritin, platelet aggregation response to ADP and arachidonic acid, Sonoclot analysis, CD41 and CD62p by flow cytometry were performed.Significant higher ferritin, Sonoclot Platelet Function, Clot Rate, and lower protein C were found in thrombotic group compared to non-complicated and bleeder group. Positive significant correlation between ACT with APTT and Sonoclot Platelet Function with ADP and arachidonic acid. Clot rate has significant negative correlation with protein C The bleeding complications in thalassemic patients were more obvious. Platelet hypoaggregation is characterized in 50% of patients, and more observed in bleeder group. Hypercoagulability causes as found are: hyperferritinemia, low protein C and to lesser extent platelet activation. Antithrombin III showed no significant difference in all comparable groups so it doesn’t add a value identifying hypercoagulability in these patients. Sonclot ACT and Platelet Function results are well corelated to APTT and platelet aggregometry respectively while Clot Rate wasn’t corelated to D-dimer or CD62p in β-thalassemia patients.